Given that miR-223 functions as an oncogene in human gastric cancer by targeting FBXW7 [16], and that genistein treatment significantly inhibited miR-223 expression but up-regulated FBXW7 in PDAC cells [7], we further examine the involvement of FBXW7 in the effect of miR-223 in human patients with pancreatic cancer. This evidence concerns the gene FBXW7 and familial pancreatic carcinoma.