TOB2 and neoplasm: In this study, as a predic target gene of miR-363-3p, althouth we found expression of TOB2 was also significantly decreased after infecting with 363-Mimics, and TOB2 knockdown inhibited cell viability, but TOB2 overexpression in A549 and H441 cells did not significantly promote cell viability and could not abrogate miR-363-3p-induced inhibition, see Supplementary Figure 2 and Supplementary Figure 3C, indicating the role of miR-363-3p for tumor growth could not be explained by TOB2, since a miRNA could have multiple target gene and complex signal network.