EXOC3L2 and Alzheimer disease: In recent several years, large-scale genome-wide association studies (GWAS) and next generation sequencing analysis have identified a number of AD susceptibility genes including CLU [4–8], CR1 [9–11], BIN1 [12–14], PICALM [15–18], CD2AP [13, 19], CD33 [20–21], ABCA7 [7–8, 11, 13–14, 22], TREM2 [23–24], MS4A4/MS4A6E [25–29], EPHA1 [25–29], and EXOC3L2 [25–30].