When examining whether rhGRP78 promoted the proliferation of HCC cells in vivo, we noted that treatment of tumors with rhGRP78 caused a significant increase in the weight of xenograft (UT versus rhGRP78:1.21 ± 0.31 g versus 1.72 ± 0.38 g), indicating that secreted GRP78 promoted the proliferation of HCC. This evidence concerns the gene HSPA5 and hepatocellular carcinoma.