These functions include the up-regulation of EGFR levels in glioblastoma through the binding of tTG to c-Cbl, the migration of HeLa cervical carcinoma cells and MDA-MB231 breast cancer cells through an interaction with Hsp70, and the docking of cancer cell-derived microvesicles onto recipient cells through the tTG-mediated cross-linking of fibronectin [5–7]. The gene discussed is CBL; the disease is cancer.