He et al. [8] investigated the differential expression of proteins between AFPGC and AFP non-producing gastric cancer and found that high level expressions of XIAP and IGF-Irβ in tumor tissues were independent factors for poor prognosis in AFPGC patients, and that AFPGC may be separated into two subgroups with involvement of a distinct set of signaling pathways based on a risk model of XIAP and IGF-Irβ expression and TNM stage. Here, XIAP is linked to neoplasm.