To enhance verification, we applied a relaxed NGS tumour only approach using the previously described five-tool MetaSV analysis (Table 2), identifying nine of the NGM called SVs (11%) from 872 deletions, 238 duplications, and 140 inversions, of which three deletions (involving genes THSD4, ZNF438 and TBCK) and one insertion (involving gene PRMD16, Figure 3A) impacted known genes. Here, TBCK is linked to neoplasm.