BRCA2 and Familial prostate cancer: As UP2153 reported a family history of breast cancer, we assessed for potentially pathogenic mutations inherited in breast cancer genes, BRCA1 and BRCA2. This was motivated by the observation that, by age 65 years, men with predisposing BRCA1 or BRCA2 mutations are at as much as 4.5- and 8.6-fold increased risk of developing prostate cancer, respectively [14, 15], with BRCA2 mutations further associated with poor prognosis [16].