In an analysis of 333 individual prostate cancer exomes, TCGA identified seven subtypes defined either by gene fusions involving the ETS family (59% of cases), specifically ERG, ETV1, ETV4, or FLI1, or recurrent mutations (15% of cases) in SPOP, FOXA1, or IDH1 [3]. The gene discussed is SPOP; the disease is prostate carcinoma.