Of the 46 genes spanning NGM-derived somatic SVs, excluding the previously discussed fusion event, 15 have been associated with a variety of cancers including; ACTR3B, CELF2, CHL1, TSPYL2, LINGO1, MAGEA4, OLFM1, PDGFRA, PRDM16, PRKCA, RPS6KA6, SLC13A2, TBCK, UCK2, and ZMAT4. What is notable is the potential of two oncogenic driver events within the known 3p26 prostate cancer susceptibility locus [47]. The gene discussed is ACTR3B; the disease is cancer.