ZNF438 and neoplasm: To enhance verification, we applied a relaxed NGS tumour only approach using the previously described five-tool MetaSV analysis (Table 2), identifying nine of the NGM called SVs (11%) from 872 deletions, 238 duplications, and 140 inversions, of which three deletions (involving genes THSD4, ZNF438 and TBCK) and one insertion (involving gene PRMD16, Figure 3A) impacted known genes.