To avoid the random cytotoxicity and false positive reaction of chemicals, we checked the cytotoxic effect of a group of chemicals including IPP-14 on PAK1 overexpressed pancreatic cancer cell line, MIA-Paca2 (Supplementary Figure 2A), comparing to human gastric cancer cell line, MKN45 (Supplementary Figure 2B). This evidence concerns the gene IPP and familial pancreatic carcinoma.