Another report showed that Notch1 was observed to be activated in over 81% of human HCC specimens compared to the surrounding normal tissues [17], and also, Notch3 and Notch4 were expressed highly in human HCC tissues, with Notch3 present in 78.3% of patients and Notch4 in 68.3% [15]. This evidence concerns the gene NOTCH3 and hepatocellular carcinoma.