AKT1 and breast carcinoma: In a recent paper the effects of reparixin on paclitaxel-induced signaling was studied in highly purified mammospheres derived from triple negative MDA-MB231 breast cancer cells showing that its effect in breast cancer cells was mediated by inhibition of paclitaxel/GRO/KC-induced p-FAK, p-AKT, p-STAT3 and β-catenin activation [26].