CXCR1 and neuropathic pain: On these bases, this work aimed to clarify the effect of paclitaxel on CXCR1-CXCR2 dependent pathways in neuropathic pain and to elucidate the effect of a known CXCR1-CXCR2 inhibitor, reparixin, in counteracting neuropathic pain behavior and biomarkers in the CIPN context.