CXCR1 and peripheral neuropathy: Also, the results of a recently completed phase Ib trial in metastatic breast cancer, showed that combination of reparixin with weekly paclitaxel resulted in a sizeable response rate with a low incidence and severity of peripheral neuropathy, suggesting that taxane-induced neurological toxicity, but not antitumor activity, may be reduced by CXCR1/2 inhibition [27].