The ability of NHS-IL12 in the presence of an anti-PD-L1 antibody to (a) induce IFN-γ production, which promotes PD-L1 expression levels, (b) enhance T cell activation via changes within the immunological synapse and (c) activate NK cells could contribute to tumor destruction through antibody-dependent cellular cytotoxicity (ADCC) [29]. The gene discussed is CD274; the disease is neoplasm.