Only the combined treatment of the rat anti-PD-L1 antibody and NHS-muIL12 resulted in a statistically significant inhibition of bladder tumor growth [**, P = 0.0021; control antibody vs. anti-PD-L1/NHS-muIL12, ***P = 0.0002; NHS-muIL12 vs. anti-PD-L1/NHS-muIL12 (Mann-Whitney test)]. Here, CD274 is linked to urinary bladder neoplasm.