In terms of mitochondrial changes, Pirc rats harboring adenomas/tumors had increased mitochondrial fission (1.45 fold increase in DRP1, p = 0.09), increased mitochondrial fusion (1.61 fold decrease in OPA1, p = 0.022), increased mitochondrial biogenesis (1.65 fold increase in PGC1-α, p = 0.038) and mitochondrial uncoupling (2.01 fold increase in UCP2, p = 0.05) (Figure 3B). Here, PPARGC1A is linked to adenoma.