KLF3 and colorectal carcinoma: In the multivariate analysis, after adjustment for all potential prognostic factors including age, N stage, and M stage, we found that age (HR, 1.034; 95% CI, 1.013–1.056, P=0.001), N stage (HR, 1.535; 95% CI, 1.155–2.042; P=0.003), M stage (HR, 2.250; 95% CI, 1.472–3.439; P<0.001), and KLF3 (HR, 0.473; 95% CI, 0.230–0.831, P=0.012) were the four prognostic factors for OS in patients with CRC (Table 2).