We have found that levels of FAcilitates Chromatin Transcription (FACT) complex in BrCa correlate with poor overall survival, presence of clinical markers of bad prognosis (e.g. high grade of disease, triple negative status, HER2 amplification, and absence of estrogen receptor), and high probability of metastatic disease [1, 2]. The gene discussed is ERBB2; the disease is invasive breast carcinoma.