BBC3 and colorectal carcinoma: Based on the representation of miR-503-5p recognition sites in their 3′ UTRs, we found that one of the candidate target genes, PUMA, showed reduced expression of mRNA and protein levels in HCT116-OxR and HT29-OxR cells compared to their parental cells (Figure 1B & 1C), suggesting that miR-503-5p might induce oxaliplatin resistance in CRC cells by targeting PUMA.