TNF and alkaline phosphatase measurement: Its pathogenic mechanism is still not very clear, while a common view is that the interaction of proinflammatory cytokines such as interleukin (IL)-1, tumor necrosis factor (TNF), IL-6, IL-8 and IL-4 with components of the anti-inflammatory response system, such as IL-10, causes severe complications of AP including pancreatic necrosis [5].