TGFB1 and Hepatic fibrosis: In response to liver damage, the quiescent HSCs are activated and differentiated into fibrogenic myofibroblast-like cells, which express many ECM proteins including collagen type-I, α-smooth muscle actin (α-SMA), transforming growth factor-β (TGF-β), matrix metalloproteinase (MMP), and tissue inhibitors of metalloproteinase, which contributes to liver fibrosis [7].