EGFR family members by homo- or hetero-dimerization activate several downstream pathways, including Ras/Raf/MAPK/ERK, PI3K/Akt, STAT and the PLC-γ signaling pathways [12, 13] that potentiate the growth and survival of tumor cells and cancer stem cells (CSCs) [14]. The gene discussed is AKT1; the disease is neoplasm.