Although the role of TnTs in cancer development and/or tumor dissemination is not known, the recent report of Osswald et al. [13] showing that astrocytoma cells use long membrane protrusions, morphologically similar to those reported here, as routes for brain invasion and proliferation suggest that disruption of TnTs may benefit the clinical course of cancer patients. This evidence concerns the gene TNNT1 and astrocytoma (excluding glioblastoma).