CXCL12 and cancer: Therefore, our data demonstrate that miR-93-5P and miR-106b-5P negatively regulate CXCL12 and CD274 expression in both cancer cells and MDSC, and that BET inhibitors represent a suitable upstream modality to control expression of CXCL12 and CD274 via transcriptional regulation of the miR-25-93-106b cluster.