ERCC2 and central nervous system cancer: In 2014, Adel Fahmideh et al [21] conducted a systematic review and meta-analysis to investigate the association between DNA repair gene polymorphisms (ERCC1 rs3212986, ERCC2/XPD rs13181, MGMT rs12917, PARP1 rs1136410, and XRCC1 rs25487) and risk of glioma.