We found that in patients with lung adenocarcinoma, expression of HK2 and GBE1 were positively associated with tumor size (P=0.0175, P=0.0018), tumor stage (P=0.00174, P=0.003) and TNM classification N staging (P=0.0256, P=0.0249), respectively. The gene discussed is GBE1; the disease is neoplasm.