IGHE and allergic disease: The morbidity associated with tick bite allergy has been associated with the direct effect of immunoglobulin E (IgE) response to tick salivary antigens [7–10], or secondary to the induction of allergy to red meat consumption through IgE antibodies against the carbohydrate α-Gal (Gal α 1-3Gal β 1-(3)4GlcNAc-R) [11–20].