Supporting a possible role for miR-494-3p in PMF pathogenesis, among its 86 downregulated targets there are several genes that have been described as tumor suppressor genes (CUL3 [29], KLF11 [30], TRAF3 [31] and SOCS6 [32]) as well as genes whose low expression has been associated with the development of myeloid malignancies such as ARID4B [33], PURB [34], ELF2 [35] and RAD23B [36]. This evidence concerns the gene CUL3 and myeloid neoplasm.