These signaling pathways, along with activating secondary pathways, like PI3K–AKT, RAS/MAPK, p38 MAPK and JUN N-terminal kinase, regulate the pathogenesis and progression of tumor as they control cell proliferation, migrations, differentiation, apoptosis, and angiogenesis [36, 37] (Figure 8). This evidence concerns the gene MAPK8 and neoplasm.