CAMK2A and epilepsy: Promotes NT-4 expression, NT-4 can promote neuron survival, alleviate neuronal injuries, inhibit neurons from apoptosis and adjust the synapses plasticity [24].Indirectly inhibits mossy fibers sprouting and adjust the synaptic reconstructions by inhibiting the expression ofN-Cadherin [24].Inhibits calcium overload to prevent an epileptic episode induced by Mg2+ deficiency [28].Promotes the expression of CaMK IIα to prevent the onset of epilepsy [28].