The implementation of our customized NB-panel in 106 primary neuroblastoma patients confirmed some of previously reported mutated genes in neuroblastoma with very similar frequencies, including ALK (11% of the patients) [17–21], NF1 (14%) [22], ATM (15%) [23], and others with lower frequency such as ATRX (3%) [20, 21], ARID1A (3%) [24] and STK11 (1%) [25]. Here, ATRX is linked to neuroblastoma.