Despite its lower frequency, CRHR1-KANSL1 is of interest as it reside at the locus 17q21.31, a structurally complex genomic region containing a 900-kb inversion polymorphism, multiple copy-number variants [27, 28], and markers that associate with ovarian cancer [29], female fertility [28], and female meiotic recombination [28]. The gene discussed is CRHR1; the disease is ovarian cancer.