MMP13 and cancer: We also detected upregulation of genes involved in cancer metastasis and cancer stemness (FOXC2, SNAI2, CXCRs, and IGF1), cell stemness (NANOG, POU5F1, and KLF4), metalloproteinases (MMP7, MMP10, and MMP13), and angiogenic factors (IL-8 and S1PR1) (Supplementary Table 1).