Assuming that PRDM14 was expressed by CSCs in these tumor tissues and was involved in aberrant epigenetic changes in cancer, that PRDM14 expression was not correlated to disease stage may be explained by the heterogeneous size of the CSC population in tumors [38,39] and epigenetic changes observed in the earliest events of cancer initiation. This evidence concerns the gene PRDM14 and neoplasm.