Silencing PRDM14 reduced the expression of miRNAs upregulated in breast cancer tissues (e.g. miR-106a, miR-149, miR-18a, miR-221, miR-222, miR-224, miR-23a, miR-24, miR-27a/b, and miR-493) and increased expression of those that were downregulated (e.g. miR-15a, miR-150, miR-183, and miR-203). Here, PRDM14 is linked to breast carcinoma.