GSEA also detected: significant overlaps between transcriptomic signatures of 8-week-old hURI-tetOFFhep mouse and the S1 HCC subclass, confirming that in early stages the model exhibits an aberrant WNT signaling pathway signature (Hoshida et al., 2009) (Figures 1C and S1A); fetal liver and p53 pathway activation signatures, respectively present in G1 and G3 subtypes (Boyault et al., 2007) (Figures 1C and S1B); and a signature associated with transforming growth factor β (TGF-β) signaling pathways that reportedly activate HPCs (Coulouarn et al., 2008) (Figure 1C). Here, TP53 is linked to hepatocellular carcinoma.