Analysis of the sequenced samples showed an average of 21.2, 23.73, 22.41 and 42.35 percent DNA methylation of most of the CpG sites among the 30 CpG sites in ABCB1 PCR product of all the samples in complicated, uncomplicated, all malaria and control (in both age-sex matched samples) groups respectively. This evidence concerns the gene ABCB1 and malaria.