It is known that methylation of the promoter is one of the major mechanisms for control of gene expression and hypomethylation of downstream promoter region of ABCB1 in malaria patient as demonstrated in our current study suggests that reduced methylation level upon infection allow trans-acting factors such as LRPPRC (leucine rich pentatricopeptide repeat multifunctional family) [80–82] and pro-inflammatory cytokines activated NF-κB, AP-1 and STAT to participate in the transcription of ABCB1 gene [27]. The gene discussed is ABCB1; the disease is malaria.