The marked organ injury in this model of melioidosis is reflected by elevated plasma markers of hepatocellular damage (aspartate aminotranspherase, AST and alanine aminotranspherase, ALT), renal failure (urea) and general cellular damage (lactate dehydrogenase, LDH), especially shortly before mortality occurs [17, 18] (Fig 3C–3F). The gene discussed is GPT; the disease is Renal insufficiency.