CAPN10 and obstructive sleep apnea syndrome: It was also believed that variation of the Calpain-10 gene (SNP 43 GG and SNP 44 TT) had connections with elevated levels of total cholesterol.[13,29] Taken together, our study assumed that SNP 43 and SNP 44 polymorphisms of Calpain-10 gene might affect the variance in Calpain-10 mRNA level so as to increase the risk of cardiovascular diseases, ultimately contributing to the development of OSAHS.