SNP 63 was identified as minor allele with the lowest allele frequency, always selected for some rare polymorphism studies; thus it was excluded in this study.[20,21] Therefore, we demonstrated the positive association between Calpain-10 SNP 43 and SNP 44 polymorphisms, and the risk of OSAHS and OSAHS with IS. This evidence concerns the gene CAPN10 and obstructive sleep apnea syndrome.