Using Calpain-10 SNP 43 and SNP 44, BMI, AHI in the OSAHS and OSAHS + IS groups as independent variables, OSAHS + IS as dependent variable, unconditioned logistic regression analysis was performed to estimate regression coefficient and calculate OR with 95% CI for risk factor of OSAHS with IS (OR > 1). This evidence concerns the gene CAPN10 and obstructive sleep apnea syndrome.