CYP11B1 and adenoma: Steroid pathway analysis results were strongly corroborated by the results of quantitative immunohistochemistry in aldosterone-producing adenoma tissue, demonstrating a significant association of intratumoral expression of the CYP11B1 enzyme, required for the synthesis of both glucocorticoids and 11β-hydroxyandrostenedione, with in vivo excretion of the corresponding steroid metabolites.