As the decision curve indicated, the base model + MRI + PZ-ratio was superior to the base model in the defined range of interest (15–40% probability) in predicting significant PCa in all patients (Figure 2A) and patients with PSA 4–10 ng/ml (Figure 2B) with a higher net benefit (Supplementary Table 5). The gene discussed is KLK3; the disease is posterior cortical atrophy.