KLK3 and posterior cortical atrophy: A total of 247 consecutive patients with PSA ≥ 4.0 ng/ml or PSA < 4.0 ng/ml but with abnormal digital rectal examination (DRE) findings were included in the study, in which 88 cases (35.6%) and 77 cases (31.2%) were diagnosed with PCa and significant PCa, respectively.