KPNA2 and hepatocellular carcinoma: In accordance with the functional results described above, our microarray analysis revealed that the corresponding pathways for dysfunction induced by KPNA2 knockdown are also enriched in KPNA2-regulated gene sets, such as the cell cycle pathways of the G2/M DNA damage checkpoint regulation and cell cycle control of chromosomal replication, which were a perfect match to the G2/M and S phase arrest observed in the human hepatocellular carcinoma cell lines HepG2 and SMMC-7721 with KPNA2 knockdown.