However, the roles of KPNA2 in tumorigenesis have not been explored comprehensively, and it has only been shown that cell proliferation and invasion are impaired in hepatocellular carcinoma cells in vitro by KPNA2 knockdown [13, 15], and in vivo roles of KPNA2 have remained to be determined. The gene discussed is KPNA2; the disease is hepatocellular carcinoma.