Indeed, the deregulated pathways enriched in differentially expressed genes induced by KPNA2 knockdown was quite in accordance with the functional effects of KPNA2 in hepatocellular carcinoma cells, which showed that KPNA2 induced cell proliferation blockade, impaired colony formation, cell cycle arrest and apoptosis. This evidence concerns the gene KPNA2 and hepatocellular carcinoma.