NOTCH4 and neoplasm: Zhang et al. recently found that STAT3 could bind promoter region of TXNDC17 and up-regulated its expression, mediating Taxol resistance via enhancing autophagy in human colorectal cancer cells [28], which may be also involved in the mechanism of chemoresistance in BC patients, whereas Bui et al. found that Notch4/STAT3 signaling induced the epithelial-mesenchymal transition in tamoxifen-resistant human breast cancer, increasing micrometastatic tumor burden [29].