Using α-mangostin, which is a xanthone derivative, to treat TRAIL-resistant human colon cancer DLD-1 cell line and breast epithelial proliferating MCF10A and found that α-mangostin curb the expression of miR-133b and relieve inhibition of miR-133b on its target gene DR5, which canceled the resistance and effectively induced the translocation of DR5 to the cancer cell surface membrane in TRAIL-resistant DLD-1 cells [22]. Here, TNFRSF10B is linked to cancer.