IGF1R and gastrointestinal stromal tumor: Fascin actin-bundling protein 1(FSCN1), which plays a critical role in cell migration, motility, adhesion and cellular interactionsin, in esophageal squamous cell carcinoma (ESCC) [61], gastrointestinal stromal tumor(GIST) [62] and gastric cancer [63], C-X-C motif chemokine receptor 4(CXCR4) and in colorectal cancer [64], IGF1R, MET, phospho-Akt and FAK in osteosarcoma [28], Gli1 in gastric cancer(GC) [65], Sp1 and its downstream proteins MMP-9 in GC [32], CTGF in HCC [35].