RHOA and malignant colon neoplasm: Similarly, miR-133b dysregulation in colon cancer cells was allegedly due to the change of transcription activity caused by TAp63, miR-133b is a transcriptional target of TAp63 so that p63 can directly drives the miR-133b expression via the binding site, what is important is that TAp63 can inhibit cells migration and metastasis by indirectly regulating the expression of target gene of miR-133b (such as RhoA) and epithelial–mesenchymal markers in colon cancer in virtue of TAp63/miR-133b axis [119].