In addition, miR-133b can mediate cancer metastasis via regulating the tumor microenvironment, previous study [66] have found a marked up-regulation of miR-1 and miR-133b in interleukin-6 (IL6)-(human prostate fibroblasts) HPFs and (cancer associated fibroblasts) CAFs, miR-133b not only is able per se to promote fibroblast activation by inducing phenotypic changes but can be secreted by activated fibroblasts and may intake further by prostate carcinoma cells, by which mesenchymal phenotype would be established, and then CAFs induce EMT in tumor cells. This evidence concerns the gene IL6 and neoplasm.