Two members of the BCL-2 family of pro-survival molecules (MCL-1 and BCL2L2 (BCLw)) as predicted targets of miR-133b have been identified in lung cancer, osteosarcoma, bladder cancer and gastric cancer (Mcl-1 and Bcl-xL), in which over-expression of miR-133b can induce apoptosis though theses apoptosis regulator in tumor cells [27–30]. Here, MCL1 is linked to osteosarcoma.