MET and osteosarcoma: Some signaling pathway can be affected by miR-133b, such as c-Met engagement activates multiple oncogenic pathways (RAS, PI3K, STAT3, beta-catenin), which itself is the Immediate target gene of miR-133b in colorectal cancer (CC) and osteosarcoma, its suppression can affected tumor cell proliferation and apoptosis in vitro and in vivo [28, 37, 38].