PPP2R2D and hepatocellular carcinoma: B55δ, encoded by the PPP2R2D gene, can increase the suppressive effect of cisplatin (cDDP) in Hepatocellular carcinoma (HC), miR-133b was up-regulated in HC cells and directly target PPP2R2D and suppress its expression and further disrupt its effect in improving chemotherapeutic sensitivity [69].