In glioma and hepatocellular carcinoma, miR-133b inhibit its target gene silent information regulator 1 (Sirt1) and then suppress cell proliferation and invasion together with increasing apoptosis, the specific influence mechanism may be the miR-133b/Sirt1/GPC3/Wnt β-catenin pathway, by which a series of genes such as Bcl-2, Bcl-xL, Mcl-1 and E-cadherin were regulated [39, 40]. The gene discussed is SIRT1; the disease is hepatocellular carcinoma.