Notwithstanding the fact that EGFR gene are commonly present in cancer, while there is a significant decrease in the expression of EGFR in glioblastoma (GBM) microvasculature, for the platelet-derived growth factor receptor beta (PDGFRB), involved in GBM angiogenesis, occupy the primary position in microvascular proliferation, one of the reason is several elevated expression of miRs, including miR-133b, targeting and curbing EGFR [56]. The gene discussed is EGFR; the disease is glioblastoma.