Yet expect all the apoptotic pathways, miR-133b can regulate genes closely related to proliferation, such as fibroblast growth factor receptor 1 (FGFR1), and Sp1 and its downstream proteins Cyclin D1 in gastric cancer [31, 32], TATA-box binding protein like 1(TBPL1) in colorectal cancer [33], the human ether-a-go-go-related gene potassium channel (hERG, Kv11.1, KCNH2) in glioma [34]and connective tissue growth factor(CTGF) in hepatocellular carcinoma (HCC) [35]. The gene discussed is SP1; the disease is colorectal cancer.