The relationship between miR-133b and epidermal growth factor receptor (EGFR) separately discussed here mainly because the fact that miR-133b target EGFR or alter EGFR-specific genetic pathways have been found in several human cancer, such as ovarian cancer (OC) [48], prostate cancer (PC) [49], bladder cancer [50], (non-small-cell lung cancer) NSCLC [51], colorectal cancer [52]. The gene discussed is EGFR; the disease is colorectal cancer.