Tumor necrosis-factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-superfamily that selectively induces apoptosis through death receptors (DRs) 4 and/or 5 in cancer cells, however, cancer cells can evade TRAIL-induced apoptosis by acquiring TRAIL-resistance [21]. The gene discussed is TNFSF10; the disease is cancer.