AR and Familial prostate cancer: Interesting, miR-133b, recognized as androgen receptor (AR)targets, can promoting cell survival and proliferation in the androgen-dependent PCa cells by represses CDC2L5, PTPRK, RB1CC1, and CPNE3 [24], RB1CC1, which regulate cell growth, cell proliferation, apoptosis, can be repressed by miR-133b in less aggressive LNCaP prostate cancer cells [25].