Moreover, the response rate of esophageal squamous cell carcinoma (ESCC) patients to paclitaxel-based chemotherapy was significantly higher in combined miR-133a/b downregulation group [74], miR-133b contributes to arsenic-induced apoptosis in glioma cells [34] and the joint utilization of miR-133b and cetuxima can enhance suppression effect on the growth and invasion of colorectal cancer cells by modulating EGFR [52]. Here, EGFR is linked to esophageal squamous cell carcinoma.