In mice injected with TLR3 down regulated HCT116 cells, the mean (+/- SEM) tumor weight of the mice treated with reovirus was 115 (+/- 8) mg, and was significantly lower than the tumor growth in the untreated mice, 1698 (+/- 84) mg (p = 0.000081; 93.2% reduction; Figure 6). Here, TLR3 is linked to neoplasm.