TLR3 expressing commercial HEK-BlueTM-hTLR3 cells were treated with reovirus at 50 multiplicity of infection (MOI) or poly (I:C), the positive control for TLR3 to confirm that TLR 3 is the host pattern recognition motif of the cellular machinery that is responsible for the detection of dsRNA reovirus (Figure 1). Here, TLR3 is linked to infection.