MMP16 and colorectal carcinoma: For TCGA and GSE39582 database lacks some important clinicopathological features (eg. lymphovascular invasion and perineural invasion) and therapy information (eg. radical resection or palliative resection), we then validated clinical value of MMP16 in in-house database and confirmed that high MMP16 expression in CRC was negatively correlated with both OS and DFS.