Interestingly, we have shown that GLP-1 receptors are in the top 10 GPCRs expressed by both mouse and human islets, so discoveries of the beneficial effects of GLP-1 agonists on glucose homeostasis in mice are directly translatable to the human situation, as is seen with the successful use of stable GLP-1 analogues as T2D therapies. Here, GCG is linked to type 2 diabetes mellitus.