We therefore quantified KISS1 and KISS1R expression in a TNBC cDNA array (Origene) and found that the mRNA levels of both genes were significantly greater in 20 TNBC primary breast tumors, compared to 10 normal breast tissue biopsies (Fig. 1A,B; p = 0.006 for KISS1 and 0.008 for KISS1R, Table 1). This evidence concerns the gene KISS1 and breast neoplasm.