ZFPM1 and hemorrhagic disease: Although most of the ZFPM1 deleted patients did not show bleeding disorders, the role of ZFPM1 in hematopoiesis is reinforced by the demonstration that knockout mice are severely affected by thrombocytopenia.23 On the other hand, many variants in genes related to thrombocytopenia show variable expression.24 Moreover, ZFPM1 and GATA1 interact both functionally25 and physically,26 and disruption of the normal interaction of ZFPM1 and GATA1 has been linked to a range of inherited blood disorders.27