ZFPM1 (FOG1) is also crucial for a correct eye development through the interaction with other GATA factors and its haploinsufficiency seems to be associated with severe astigmatism, as reported in our cases 1, 3, 6 and 7, and patients 3 and 4 in Willemsen et al16 (Supplementary Tables S1 and S2, Figure 2). This evidence concerns the gene QRSL1 and Astigmatism.