Cadherins are expressed in the entire human brain and their dysregulation so far has been associated with many neuropsychiatric disorders, including intellectual disability, schizophrenia and epilepsy.33 Regarding specifically CDH15, Bhalla et al34 identified four heterozygous non-synonymous variants in unrelated female patients with mild-to severe intellectual disability. The gene discussed is CDH15; the disease is epilepsy.