TP53 and sarcoma: For example, 79% heterozygous p53-deficient (p53+/−) mice developed spontaneous sarcomas via induction of p53 loss of heterozygosity at a mean time of 35 weeks after a piece of plastic plate (1 mm × 5 mm × 10 mm, polystyrene, used as a culture dish) was subcutaneously implanted [128].