TGFA and hepatocellular carcinoma: They found that the gene expression pattern in HCC from c-MYCtg and c-MYC/E2F1tg transgenic mice were very similar to those with a better prognosis and survival rates in human HCC, while the expression pattern of HCC tissue from c-MYC/TGFα transgenic animals were closely associated with the poor survival group of human HCC patients [47].