MYC and hepatocellular carcinoma: HCV in hepatocytes increases c-MYC expression in in different scenarios: (i) Non-tumoral liver tissue of HCV-infected patients with or without HCC; (ii) In hepatocyte cell lines harboring an HCV replicon and the infectious HCV strain JFH1; and (iii) In an in vivo transgenic murine model expressing the complete HCV open reading frame (ORF) in a liver-specific manner [108].