Among FABP, FABP4 and FABP5 are members of the intracellular lipid-binding protein family predominantly expressed in adipose tissue with evidence from experimental studies [16–18] and also in clinical studies as being involved in insulin resistance, with registering additive effect of FABP4 and FABP5 on metabolic-inflammatory CVD risk and atherosclerosis in humans [19], which might raise the potential usefulness of evaluating FABP4 and FABP5 as biomarkers of increased metabolic cardiovascular risk in diabetic patients. This evidence concerns the gene FABP4 and atherosclerosis.