Four stress kinases have been identified that are involved in the SG formation when cells are exposed to distinct types of stresses: double-stranded RNA (dsRNA)-dependent protein kinase (PKR) senses dsRNA during viral infection; protein kinase R–like endoplasmic reticulum kinase (PERK) detects unfolded proteins in the endoplasmic reticulum; heme-regulated inhibitor kinase (HRI) monitors changes in heme levels; and general control nonderepressible 2 kinase (GCN2) senses amino acid starvation, ultraviolet damage, and viral infection (Yamasaki and Anderson, 2008). The gene discussed is EIF2AK4; the disease is viral infectious disease.