TYMS and neoplasm: If a patient is fit for perioperative chemotherapy, screening their tumor for HER2, EGFR, PD-L1, ERCC1, TUBB3, TS, RCF, TOPOI, and TOPO2A would be a straightforward way to inform the oncologist which proteins in the patient’s tumors are prime targets and which proteins could potentially act as resistance molecules for EC drug options (Figure 1).