The decrease in cerebral GLUT3 protein levels in the animals in the present study concomitant with high levels of circulating insulin and leptin is in agreement with results from a recent paper showing that neonatal overnutrition in mice causes increased adult body weight, hyperleptinaemia, hyperinsulinaemia, and decreased GLUT3 levels in the hypothalamus [40]. This evidence concerns the gene INS and overnutrition.