On the other hand, the CD97-LPAR1 heterodimer was shown to mediate the lysophosphatidylethanolamine-induced intracellular Ca2+ increase in MDA-MB-231 breast cancer cells by the pertussis toxin (PTX)-sensitive Gαi/o protein and phospholipase C (PLC) (40). Here, ADGRE2 is linked to breast cancer.